Cancer Immunlogy
Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Immunotherapy stimulates the body's immune system, and can be a powerful treatment...
View ArticleRole of Lifestyle and Diet in Cancer
Professor Tim Key tells us about the role of life style and diet in the development of cancer. Although smoking is still the most important cause of cancer, we now know that obesity and high intakes of...
View ArticleGenome Integrity
Dr Opher Gileadi tells us how cells maintain genome integrity and how we can use it in our fight against cancer. While cigarette smoke and sun exposure can lead to DNA damage, which causes cancer,...
View ArticleAutophagy
Dr Katja Simon tells us about her research on autophagy in red blood cells. Autophagy is the cellular process in which cells degrade their toxic waste and damaged organelles. In order to fit through...
View ArticleRenal Disease
Professor Chris Pugh tells us about the links between genetics, renal disease and oxygen sensing. The kidney plays a central role in our metabolism, by controlling various physiological balances....
View ArticleINDOX Cancer Research NetworK
Dr Raghib Ali talks about INDOX, the cancer research network in India. The INDOX Cancer Research Network is a collaboration between Oxford and twelve leading cancer centres in India. As Director of...
View ArticleCancer Metabolism
Dr Patrick Pollard tells us about his research on cancer metabolism. Cancer cells produce energy predominately through a high rate of glycolysis; it has been suggested that this change in metabolism is...
View ArticleCancer and Protein Crystallography
Professor Yvonne Jones talks about cell-cell communication and how this can help us develop new drugs. Cells communicate through receptors on their surface; however, when these finely tuned systems...
View ArticleCancer and regenerative medicine
Professor Xin Lu talks about the links between cancer and regenerative medicine. Identifying the switches that turn cell growth off and on would have profound implications for cancer medicine. If the...
View ArticlePalliative Care
Dr Bee Wee tells us about Palliative Care in Oxford and her research on end of life care and fatigue. Due to advances in medicine prolonging the lives of those with progressive, life limiting diseases,...
View ArticleTargeting epigenetics to treat cancer
Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted...
View ArticleEpigenetic modifications and cancer
Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer. Although all cells in our body have the same genome, they look different...
View ArticleCancer and innate immunity
Inflammatory signalling Dr Mads Gyrd-Hansen aims to elucidate fundamental mechanisms governing pro-inflammatory signalling during innate immune responses, and through this, to better understand how...
View ArticleStem cells and cancer
Adult gastrointestinal stem cells The gastrointestinal tract is lined with a single sheet of epithelium that is replaced every 4-5 days. The base of a flask-shaped structured called the crypt is where...
View ArticleCancer Informatics
Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us...
View ArticleCancer predisposition and evolution
Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers...
View ArticlePersonalised Medicine
Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries...
View ArticleHuman Cancer Genetics
Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. SNP - single...
View ArticleMelanoma
Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat....
View ArticleTargeting cancer mechanisms
Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Switching mechanisms within our cells are in part responsible for their...
View ArticleCleaning up misfolded proteins
Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases. Dr John Christianson's research focusses on ER-associated degradation, which...
View ArticleRepairing DNA damage
Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans. GENOME INTEGRITY Whilst controlled DNA...
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